Neonatal Nurse Practitioner Practice Exam 2026 – Complete Prep Resource

Ibuprofen is preferred over indomethacin for treating conditions like patent ductus arteriosus (PDA) in neonates primarily due to its reduced side effects on the renal system. Indomethacin can cause renal vasoconstriction, leading to decreased renal blood flow and subsequent renal impairment, which is a significant concern in premature infants who may already be at risk for renal issues.

In contrast, ibuprofen has a more favorable renal profile. It generally has less impact on renal perfusion and function, making it a safer choice for this specific population. By reducing the likelihood of renal complications, ibuprofen allows for better management of fluid balance and electrolytes in neonates, which is crucial for their overall health and development.

This aspect highlights why ibuprofen is often the drug of choice in this scenario, as preserving renal function is critically important in the management of premature infants.